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Research & Innovation

Medical Research Initiatives

Dr. V.G. Mohan Prasad and VGM Hospital have been actively involved in several medical research initiatives, including clinical trials, publications, and technological advancements in gastroenterology and hepatology.

Medical Research Initiatives

Clinical Trials & Research Studies

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  • Conducted international multi-center trials for new Mesalamine formulations in mild-to-moderate ulcerative colitis.
  • Studied Pantoprazole sodium vs. magnesium for treating GERD (Gastroesophageal Reflux Disease).
  • Researched new 5-HT3 antagonists for diarrhea-predominant IBS (Irritable Bowel Syndrome).
  • Conducted national trials for Mesalamine suppositories in ulcerative colitis.
  • Assessed the efficacy of Vedolizumab in moderate-to-severe ulcerative colitis.
  • Investigated Calprotectin as a biomarker for tuberculosis-related GI conditions.

Luminal Gastroenterology

  • Conducted international multi-center trials for sublingual interferon in chronic Hepatitis B & C.
  • Studied herbal therapies for gallstone dissolution.
  • Participated in an observational study on host and viral genotypes of chronic hepatitis cases in India.
  • Conducted pegylated interferon trials for chronic Hepatitis B & C.
  • Researched Tormogens therapy for Hepatitis C genotype 1.
  • Conducted international trials for Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF) for HBV treatment.

Hepatology

  • Compared Capsovision Capsule Endoscope with Colon 1 Capsule and colonoscopy for colonic pathologies.
  • A non-invasive technique for visualizing the GI tract.
  • Comparison of Techniques: Evaluates accuracy, efficiency, and patient comfort.
  • Detection of Colonic Pathologies: Identifies polyps, tumors, bleeding, and inflammation.
  • Advanced Imaging: Enhanced visualization with AI-assisted analysis.
  • Patient Benefits: Minimally invasive, no sedation, and improved diagnostic accuracy.

Endoscopy Research

  • Pyogenic Liver Abscess in a Tropical Country – American Journal of Gastroenterology.
  • Hepatitis C Genotyping and Distribution in India – Journal of Clinical Microbiology.
  • Transvaginal Endoscopic Appendectomy – World’s First Report – Surgical Endoscopy.
  • Intestinal Parasites in Capsule Endoscopy – Gastrointestinal Endoscopy Journal.
  • On-Treatment HBsAg Kinetics in Genotype D Hepatitis B – Hepatology International.
  • Metadoxine vs. Placebo in Non-Alcoholic Steatohepatitis (NASH) – Randomized Controlled Trial.
  • Indian Consensus on Chronic Constipation in Adults – Indian Society of Gastroenterology.

Published Medical Research

  • Hemoseal Spray (Shaili®) – An endoscopic device to control gastrointestinal bleeding.
  • Capsule Endoscopy – First to introduce in India for diagnosing obscure GI bleeding.
  • SpyGlass DS Cholangioscopy – First in Tamil Nadu, used for direct bile and pancreatic duct evaluation.
  • Power Spiral Enteroscopy – First in Tamil Nadu, enabling deep GI tract interventions.
  • Natural Orifice Transluminal Endoscopic Surgery (NOTES) – Performed India’s first transvaginal appendectomy.
  • Urea Breath Analyzer & Hydrogen Breath Test – Introduced novel methods for detecting H. pylori and food intolerances.

Technological Innovations